Early game · first 8 minutes
Use cover against Vexing Bolt and clear Spectral Assistant when you can shoot it safely. Land repeated Screwjab Dagger hits on Sinclair while keeping a route back to cover.
Vyper vs Sinclair
54.9% win rate as Vyper · 5,811 matches
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Mid game · Walkers
Pressure Sinclair when Rabbit Hex is unavailable, while watching the Spectral Assistant he can swap to. Use your ultimate when it helps the fight; withholding it does not prevent Audience Participation from choosing it.
Late game · Patron
Keep space against Rabbit Hex’s area upgrade, and respond to the copied ultimate when Sinclair uses it. Pressure him after his escape or protection is spent, while keeping a route back to your team. Apply Lethal Venom to Sinclair, then land a direct Petrifying Bola hit to hold him. Venom can damage him while petrified; save ordinary gun and Screwjab Dagger damage until the protection ends.