Early game · first 8 minutes
Stop attacking during Riposte; bullets can trigger it too. Attack after it ends, keeping room to dodge Flawless Advance. Then land repeated Screwjab Dagger hits on one enemy to increase its damage and slow.
Vyper vs Apollo
48.3% win rate as Vyper · 8,862 matches
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Mid game · Walkers
Attack Apollo with a teammate from separate positions so one Itani Lo Sahn cannot catch both of you. Keep your strongest attack for after Riposte ends, and avoid following Disengaging Sigil into his teammates.
Late game · Patron
Move out of Itani Lo Sahn’s path during its wind-up. Apollo is invulnerable during the slash sequence; when it ends, protect the affected ally and attack him together. After the slash sequence ends, apply Lethal Venom to Apollo, then land a direct Petrifying Bola hit to hold him. Venom can damage him while petrified; save ordinary gun and Screwjab Dagger damage until the protection ends.